pharma

Pharmaceutical & Biological

IKA know-how for the pharmaceutical industry

IKA is known worldwide to be a respectable and reliable partner of the pharmaceutical industry. The portfolio of IKA includes machines and equipment used for the production of homogenous emulsions and suspension as well as for drying and mixing of free-flowing solids. IKA innovative mixing technology covers the entire spectrum of pharmaceutical production: from products low in viscosity such as injections and cough syrup to highly viscous products such as suppositories and dental masses.

Thanks to its long-standing experience and continuous collaborations with pharmaceutical companies, IKA is able to fulfill even the most challenging demands that arise in the pharmaceutical industry today. IKA will support you consistently, starting with product development all the way to mass production. A smooth process is made possible due to experienced teams of specialists and a series of state-of-the-art equipment: On the one hand engineering and software teams, on the other hand a pilot plant station, a design office, production facilities and a well-coordinated service department.

IKA machines and equipment for the pharmaceutical industry representing up-to-date technology and are:

  • of high quality and designed based on FDA or EDEHG standards
  • completely drainable
  • suitable for CIP and SIP
  • made from high-quality material (all parts)
  • equipped with seals suitable for pharmaceutical applications
  • deliverable in an explosion-safe design
  • scalable on a lab scale all the way to production

The American Food and Drug Administration (FDA) confirmed the high quality and hygienic design of IKA machines and equipment with its bestowal of the 3-A certificate. Per customer request we are able to use alternative, high-quality materials when it comes to special production demands. The surfaces touched by the product can be produced in any desired quality.

With IKA mixing technology are produced:

  • Tablets
  • Vaccines
  • Injection solutions
  • Antibiotics in the oil
  • Plant extracts
  • Ointments
  • Silicone emulsions
  • Penicillin emulsions
  • Gelling agents
  • Medical gels
  • Cough syrup
  • Suspensions
  • Wax emulsions
  • Suppositories
  • Powder drugs
  • Vitamins
  • Food additives
  • Dental materials
  • Transdermal patches

Example Applications

Silicone emulsions
Production in an inline process

Production of a silicone/water-emulsion

It is recommended first to make a preparation with little water (approx. 15%) and to produce a gel-like emulsion. The suitable machine for this purpose is a Colloid Mill of the type IKA® MK 2000/.. with a stronger motor (approx. 30 kW, 1.000 l/h). Moreover it has to be worked with high shear gradient.
As soon as a homogeneous, transparent and very viscous mixture is reached, any requested viscosity can be adjusted by further mixing of water and emulsifier.

Wax emulsions
Production in a batch process
There are paraffin emulsions of the most different types, used either for water repellent finishing or for coating of medical active substances.
The main process step is the melting of the wax at moderate stirring, e.g. with the IKA® TURBOTRON®. After that the additives and the hot water are added and dispersed in circulating operation.

Best suited for this process are the IKA® inline dispersing machine of type DISPAX-REACTOR® DR 2000/.., ULTRA-TURRAX® 2000/… or Colloid Mill MK 2000/..

Crystalline Solids

Crystalline solids are found in a number of products including the drug coatings on medical devices, deodorants, and colognes. These solids often contain an active agent, which is to be released over time. Thus, proper preparation is necessary to ensure the end product performs as prescribed. IKA® Works can assist processors with equipment to wet mill the solids to a desired particle size and / or create a uniform suspension of the solids in a liquid.

ADVANTAGES OF IKA® WORKS MIXERS FOR WET MILLING / SUSPENDING CRYSTALLINE SOLIDS

Improved product quality. The high shear mixing action (see Tech Info for more details) of an IKA® Works high shear mixer ensures a uniform suspension of the solids, improving product quality and uniformity.

Decreased process time. Processors historically had to choose between a lengthy milling time or a poor particle size distribution. IKA® Works addresses these issues through the use of innovative Generator designs, which ensure both rapid process times and tight particle size distributions.

IKA® MIXERS SUITABLE FOR WET MILLING / SUSPENDING CRYSTALLINE SOLIDS

Batch: MSM, UTC, UTE, UTS, RT, RK, RKG

Inline: HED, UTL, DR, DRS, CMS, MHD, MK, MKO, Master Plant

Tablet Coatings

Tablet coatings are placed on pills to ease swallowing, disguise tastes, or control the release of a drug into the body. The manufacture of a tablet coating often involves the dispersion or hydration of several powders (i.e. cellulose based binders, sugar, pigment, etc.) into a either a solvent or water base. The challenge to the processor is to find hygienic equipment capable of effectively blending the variety of powders necessary to make a tablet coating. IKA® Works has a full range of mixers, ideally suited to manufacturing these products.

ADVANTAGES OF IKA® WORKS MIXERS FOR MANUFACTURING TABLET COATINGS

Ease of cleaning. IKA® Works 2000 Series Mixers are self draining, crevice free, suitable for CIP / SIP, and designed to meet FDA, 3A, and EHEDG standards.

Improved product quality. The high shear mixing action of an IKA® Works Mixer ensures that even the toughest solids are dispersed into a smooth, agglomerate free blend.

Reduced process time. Utilizing a high shear mixer allows processors to disperse or hydrate difficult powders in a fraction of the time required with conventional methods.

IKA® MIXERS SUITABLE FOR MANUFACTURING TABLET COATINGS

Batch: UTE, UTS
Inline: UTL, DR, DRS, CMS, MHD, MK
Master Plant

Protein Extraction

Proteins are obtained from natural sources (plant or animal tissue) through solvent extraction. This is accomplished by first rupturing the cells and then allowing the solvent to come into contact with the protein contained within. Careful application of shear is necessary, following cell rupture, to avoid damage to the protein. IKA® Works wide range of mixers allow us to tailor a solution specific to a customer’s application.

ADVANTAGES OF IKA® WORKS MIXERS FOR PROTEIN EXTRACTION

Increased yields. Utilizing innovative Generator designs, IKA® Mixers are capable of achieving excellent levels of cell rupture, bringing the maximum amount of protein in contact with the solvent.

Undamaged molecular structures. Carefully applying high shear coupled with slow speed / low shear agitation allows IKA® Customers to extract proteins without damaging the molecular structure.

Scale-up expertise. Unlike competitors, IKA® Works maintains constant shear rates across our line of mixers. Therefore, scale-up from laboratory to pilot plant to production does not have any unpleasant surprises.

IKA® MIXERS SUITABLE FOR PROTEIN EXTRACTION

Batch: RKG, RFG

Inline: DRS, MK
Master Plant

Hotline

If you have any further questions regarding our products and services, our team of advisers will be happy to help:
+1 910 452 7059